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Previous months:
2025 - 2505(2) - 2506(1) - 2512(1)
2026 - 2602(1) - 2603(1) - 2605(3)
Any replacements are listed farther down
[9] ai.viXra.org:2605.0070 [pdf] submitted on 2026-05-29 23:35:52
Authors: Keiji Yoshimura
Comments: 8 Pages.
Sleep is widely associated with homeostatic recovery, local use-dependent regulation, and state-dependent reorganization of network interactions. This manuscript proposes the Dynamical Threshold Theory of Sleep, a mathematical and computational prototype in which a multicellular biological system is represented as a network of adaptively coupled oscillatory elements with local homeostatic load, local sleep propensity, and selectively protected interactions.In this framework, wakefulness is modeled as a noisy adaptive synchronization regime under continued perturbation, whereas sleep emerges when the joint accumulation of local load and degradation of local coherence drive the system across a collective dynamical threshold into a sleep-dominant renormalization phase. To avoid the unbounded-coupling pathology of naive adaptive phase-oscillator models, the sleep-dominant subsystem is formulated as a bounded gradient flow of a reduced free energy.Numerical proof-of-concept simulations on hierarchical modular small-world networks reproduce three central features of the proposed framework: spatially heterogeneous accumulation of homeostatic burden, rapid growth of mean sleep propensity into a sleep-dominant regime, and bounded global downscaling of mean coupling strength toward finite fixed points. Additional analyses indicate that edges with stronger pre-sleep protection are preferentially preserved during sleep, consistent with selective down-selection rather than uniform weakening.This manuscript should be read strictly as a reduced network-dynamical prototype for sleep-like recovery transitions in adaptive multicellular systems. It is not medical advice, not a clinical sleep model, not a diagnostic or treatment tool, and not a claim of validation against human or animal sleep data.
Category: Physics of Biology
[8] ai.viXra.org:2605.0040 [pdf] submitted on 2026-05-20 18:46:44
Authors: Alberto Coe
Comments: 15 Pages.
The Topological Polar Surface Area (TPSA) is a core molecular descriptor in pharmacology, whose spatial distribution across chemical spaces has historically been treated as a continuous variable. This study introduces a normative geometric framework in which TPSA is quantized as a function of the fundamental Bohr area unit L0=a_0^2=28003 Å^2. Utilizing a pure logarithmic grid model (m=0) derived from a three-dimensional spatial resonance constant A=1.1547, we evaluated three independent datasets:120 clinically approved synthetic drugs, and 50 failed or market-withdrawn compounds.The results reveal a radical statistical asymmetry: the successful drug cohort structurally couples to the discrete nodes of the lattice with extreme mathematical significance (P = 0.0002) and a compressed mean residual of 0.030. Conversely, the failed drug cohort exhibits a distribution indistinguishable from stochastic background noise (P-value 0.30). This paper elucidates the computational behavior of Monte Carlo simulations under highly dense grid topologies and formalizes a zero-parameter biophysical screening route capable of pre-clinically anticipating molecular viability.
Category: Physics of Biology
[7] ai.viXra.org:2605.0012 [pdf] submitted on 2026-05-07 19:26:11
Authors: Alberto Coe
Comments: 6 Pages.
The Topological Polar Surface Area (TPSA) is a critical descriptor in pharmacology, yet itsdistribution across natural toxins has long been considered stochastic. This study proposes anovel geometric framework where TPSA is quantized as a function of the Bohr area unit (au2080² ≈ 0.28003 Ų). By applying a harmonic resonance model based on a modified Euler’s constant �� = �� − 2/3, we analyzed 28 diverse natural toxins, ranging from Hydrocyanic Acid to Maitotoxin. The results reveal a discrete double octave grid (Nodes 23 to 39) that accounts fortoxin dimensions with a mean residual of 0.18 (in node space) and a high level of significance. A Monte Carlo simulation confirms the model's validity with a significance level of P = 0.0056. These findings suggest that the chemical space of natural toxicity is governed by a fundamental area-scaling law rooted in quantum constants, offering new predictive capabilities for molecular toxicology.
Category: Physics of Biology
[6] ai.viXra.org:2603.0018 [pdf] submitted on 2026-03-03 09:05:46
Authors: Forrest Bishop
Comments: 18 Pages.
The universal genetic code exhibits chemical coherence at codon position 2: U-block codons encode predominantly hydrophobic amino acids, A-block codons encode predominantly polar and charged amino acids. We present three independent categories of evidence that this organization is load-bearing—that disruption imposes measurable costs on translation accuracy, regulatory efficiency, or both. First, aminoacyl-tRNA synthetase class distribution correlates with position-2 nucleotide, ribosome geometry enforces position-2 discrimination, and cells have built functional dependencies (membrane targeting, nitrogen metabolism) on this organization. Second, natural genetic code variants preserve position-2 chemistry at high rates: seven distinct stop-to-sense amino acid targets across two codon types all preserve position-2 block identity (p < 2.3 × 10u207bu2074 against a random null; chemistry cannot confound these events because stop codons encode no prior amino acid); three of four sense-to-sense reassignments preserve block chemistry, with the single violation requiring ongoing translational ambiguity and extensive genomic renovation. Third, regulatory gene scaling (R ~ N^γ, γ ≈ 1.7-2.0) creates a complexity ceiling at ~16,000 prokaryotic genes; hierarchical organization by position-2 block identity reduces this overhead. Position-2 chemical coherence is not an incidental pattern but a mechanical constraint: violations are possible but costly, and cumulative disruption is prohibitive.
Category: Physics of Biology
[5] ai.viXra.org:2602.0047 [pdf] submitted on 2026-02-10 20:35:45
Authors: Guiffra Patrick
Comments: 21 Pages.
In this article, we demonstrate the emergence of a fundamental structure inherent to prime numbers that embeds its signature within the molecular architecture of DNA. By constructing a harmonic field Ω(x, q) based on modular inverses of prime numbers, we show that helical periodicities of biological structures emerge naturally from universal arithmetic properties.Our main results establish that: (1) The prime number p = 11 acts as a universal pivot, generating through its modular inverse 11−1 ≡ 2 the characteristic wavelengths of protein α-helices (λ = 7/2 = 3.5, 2.68% error vs observed 3.6) and B-form DNA (λ = 21/2 = 10.5, 0.10% error vs observed 10.5). (2) Analysis of human chromosome 1 reveals statistically significant 36% enrichment of prime-length tandem repeats (p < 3.2 × 10−7). (3) We establish a universal scaling law relating the prime harmonic coherence coefficient χ to genomic fractal dimension D according to D = 1−0.86χ, validated across five organisms spanning three domains of life (bacteria, yeast, plant, insect, mammal) with near-perfect correlation (r = −0.9974, p < 10−4, errors < 1%). The numerical evidence is compelling. To claim that prime numbers constitute the fundamental template of DNA requires only one more step: experimental laboratory demonstration. We propose testable protocols involving synthesis of DNA optimized according to prime harmonic principles, with quantitative predictions for thermal stability, mutation rates, and spectral properties. If validated, these findings suggest that number theory encodes universal architectural constraints on biological self-assembly.
Category: Physics of Biology
[4] ai.viXra.org:2512.0090 [pdf] submitted on 2025-12-26 23:44:25
Authors: Moninder Singh Modgil, Dnyandeo Dattatray Patil
Comments: 6 Pages.
When Hahnemann was developing his system of medicine, there was no well established theory of atoms or molecules - consequently no one objected that the very high dilutions that he was using would remove all traces of the original mineral.This objection to Homoeopathy is a reltaively modern one. Modern atomic theory of matter has come to be well established only in past hundred years or so. So the intellectual resistance to Homoeopaty is understandable in light of Kuhn’s ideas,but how should one regard efficacy of Homoeopathy, keeping in mind Popper’s theory for change in scientific theories? One possible logical conclusion would be that the atomic theory of matter may not right. Other explanations have also been suggested, such as the so called ’memory of water’, without much success, however.
Category: Physics of Biology
[3] ai.viXra.org:2506.0068 [pdf] submitted on 2025-06-16 20:36:42
Authors: Stephen P. Smith
Comments: 4 Pages. (Note by ai.viXra.org Admin: Please list cited scientific references)
This paper explores the limitations of classical and computational models of causation in explaining life’s emergence and organization. Building on the work of Stuart Kauffman, Alicia Juarrero, and Montévil & Mossio, it proposes a novel framework: concurrent causation. Unlike linear or circular causation, concurrent causation suggests that parts and wholes influence each other simultaneously within a radically two-sided reality. It is proposed that bidirectional causality underlies biological homeostasis, development, and quantum processes such as time symmetry. The paper argues that acknowledging this hidden causal structure could reconcile paradoxes in biology and cosmology and necessitates a rethinking of scientific models and ontological assumptions. For example, Karl Ernst von Baer and Louis Bolk both pointed toward an evolutionary framework shaped by internal structuring principles, but these early pioneers could not justify their positions because causation was then limited to efficient causation. The present paper gives support for their views, and in fact offers a neo-vitalism with the recognition of concurrent causation.
Category: Physics of Biology
[2] ai.viXra.org:2505.0177 [pdf] submitted on 2025-05-24 09:31:08
Authors: Reza Ghalamghash
Comments: 13 Pages.
The demand for non-invasive aesthetic procedures has witnessed a significant surge in recent years, driven by patient preference for treatments with minimal downtime and reduced risks. Among these technologies, High-Intensity Focused Ultrasound (HIFU) has emerged as a promising modality for non-surgical skin tightening. This systematic review aims to evaluate the current evidence regarding the clinical efficacy, safety, and patient satisfaction associated with HIFU for skin tightening. A comprehensive search of major academic databases was conducted to identify relevant studies published between 2015 and 2025. The review synthesizes findings related to skin tightening in various anatomical regions, including the face, neck, and body, and examines the reported safety profiles and patient satisfaction levels. The mechanism of action of HIFU involves the delivery of focused ultrasound energy to specific skin depths, inducing controlled thermal injury that stimulates collagen production and elastin remodeling. The findings indicate that HIFU demonstrates efficacy in tightening skin, particularly in the lower face, neck, and periorbital areas, with a generally favorable safety profile characterized by mostly mild and transient adverse effects. Patient satisfaction levels are generally high, suggesting that HIFU is a well-tolerated and effective option for many individuals seeking non-surgical skin tightening. However, challenges remain, including the need for standardized treatment protocols and further research to establish long-term efficacy and optimal application across diverse skin types. Future research should focus on addressing these gaps to optimize the clinical use of HIFU.
Category: Physics of Biology
[1] ai.viXra.org:2505.0024 [pdf] submitted on 2025-05-04 10:01:11
Authors: Moninder Singh Modgil
Comments: 31 Pages.
This paper constructs a unified metaphysical-physical framework that bridges ancient cosmological wisdom with advanced field-theoretic formulations. We develop an algebraic and geometrical theory of the soul by embedding the Trilok cosmology—the three realms of the Physical World, Subtle World, and Paramdham — within a general relativistic background. Human souls are represented as $16$-dimensional Sedenion-valued fields, whose incarnations are governed by vibrational projections, karmic entanglement, and genetic periodicity across a 5000-year Time Cycle. The supreme Trigention field $Phi^{32}$, representing Shiv Baba, acts as a gravitational and vibrational attractor from the incorporeal apex. Key contributions include the introduction of soul—gene interaction fields, stochastic certainty in molecular biology, and a Lagrangian formulations, compatible with Genetics in Time Cycle (GTC). Our model synthesizes ideas from supersymmetry, quantum perception theory, and recursive brane cosmology to propose a deterministic yet vibrationally responsive path of soul evolution and liberation.
Category: Physics of Biology
[1] ai.viXra.org:2506.0068 [pdf] replaced on 2025-06-21 06:09:07
Authors: Stephen P. Smith
Comments: 5 Pages.
This paper explores the limitations of classical and computational models of causation in explaining life’s emergence and organization. Building on the work of Stuart Kauffman, Alicia Juarrero, and Montévil & Mossio, it proposes a novel framework: concurrent causation. Unlike linear or circular causation, concurrent causation suggests that parts and wholes influence each other simultaneously within a radically two-sided reality. It is proposed that bidirectional causality underlies biological homeostasis, development, and quantum processes such as time symmetry. The paper argues that acknowledging this hidden causal structure could reconcile paradoxes in biology and cosmology and necessitates a rethinking of scientific models and ontological assumptions. For example, Karl Ernst von Baer and Louis Bolk both pointed toward an evolutionary framework shaped by internal structuring principles, but these early pioneers could not justify their positions because causation was then limited to efficient causation. The present paper gives support for their views, and in fact offers a neo-vitalism with the recognition of concurrent causation.
Category: Physics of Biology